Cell Morphogenesis and Regeneration

Cells generate amazing morphologies and how these shapes are established, maintained, and in some cases even regenerated is a fascinating biological question. My work focuses on investigating mechanisms of cell morphogenesis and regeneration using two model systems, the nematode Caenorhabditis elegans and the ciliate Stentor coeruleus. In C. elegans, a powerful model system, I am using proteomic, bioinformatic, and genetic approaches to investigate mechanisms that regulate the link between cell membranes and an actively contracting actin cytoskeleton during gastrulation. In S. coeruleus, an emerging model system, I am utilizing reverse genetic approaches to investigate and characterize mechanisms of morphogenesis and regeneration in a unicellular context.